![]() Despite a modest sample size and multiple etiologies for acute clinical hepatitis, our results suggest that standard recommended doses of silymarin are safe and may be potentially effective in improving symptoms of acute clinical hepatitis despite lack of a detectable effect on biomarkers of the underlying hepatocellular inflammatory process. Patients receiving silymarin had earlier improvement in subjective and clinical markers of biliary excretion. There was a reduction in indirect bilirubin among those assigned to silymarin (p=0.012), but other variables including direct bilirubin, ALT and aspartate aminotransferase (AST) were not significantly reduced. Patients randomized to the silymarin group had quicker resolution of symptoms related to biliary retention: dark urine (p=0.013), jaundice (p=0.02) and scleral icterus (p=0.043). No adverse events were noted and both silymarin and placebo were well tolerated. Side-effects and adverse events were ascertained by self-report.įrom July 2003 through October 2005, 105 eligible patients were enrolled after providing informed consent. The primary outcomes were symptoms and signs of acute hepatitis and results of liver function tests on days 2, 4 and 7 and weeks 2, 4, and 8. The intervention consisted of three times daily ingestion of either a standard recommended dose of 140 mg of silymarin (Legalon, MADAUS GmbH, Cologne, Germany), or a vitamin placebo for four weeks with an additional four-week follow-up. The thickness varies from 0.83 mm anteriorly to 1 mm posteriorly. ![]() Anteriorly, the sclera fuses with the cornea at the limbus, and posteriorly it blends with the meninges where the optic nerve leaves the globe. The study was conducted at two fever hospitals in Tanta and Banha, Egypt where patients with symptoms compatible with acute clinical hepatitis and serum alanine aminotransferase (ALT) levels >2.5 times the upper limit of normal were enrolled. The sclera is the thick white sphere of dense connective tissue that encloses the eye and maintains its shape. Inflammation (swelling) of the gallbladder. After bilirubin is produced, jaundice may be caused by obstruction (blockage) of the bile ducts from: Gallstones. This is a randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group. Medicines, including acetaminophen toxicity, penicillins, oral contraceptives, chlorpromazine (Thorazine®) and estrogenic or anabolic steroids. In this study, our purpose was to determine whether silymarin improves symptoms, signs and laboratory test results in patients with acute clinical hepatitis, regardless of etiology. Although silymarin is hepatoprotective in animal experiments and some human hepatotoxic exposures, its efficacy in ameliorating the symptoms of acute clinical hepatitis remains inconclusive. Milk thistle or its purified extract, silymarin (Silybum marianum), is widely used in treating acute or chronic hepatitis.
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